TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5 IODO 2' DEOXYURIDINE
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چکیده
منابع مشابه
Superficial Herpetic Keratitis Treated with 5-iodo-2'-deoxyuridine.
THE results of treating herpetic keratitis with the antiviral agent 5-iodo-2'deoxyuridine have proved, after initial enthusiasm, to be somewhat variable. In most instances the number of cases analysed has been small (Bennett, 1962; Corrigan, Gilkes, and Roberts, 1962; Davidson, 1962; Kaufman and Maloney, 1962; Luntz and MacCallum, 1963). More accurate conclusions can best be reached by a double...
متن کاملTreatment of Non-gonococcal Urethritis with 5-iodo-2'-deoxyuridine.
5-iodo-2'-deoxyuridine (5IDU) is an antiviral compound which has a chemical composition closely resembling that of thymidine; the antiviral effect is thought to be due to the metabolic antagonism to the uptake of thymidine in the deoxyribonucleic acid (DNA) molecule (Prusoff, 1959). This molecule combined with protein is the main composition of the herpes simplex virus, upon the metabolism of w...
متن کاملCryogenic Treatment of Herpes Simplex Keratitis.
DURING the early stage of our experiments on the use of low temperature for cataract extraction (Krwawicz, 1961, 1963), we had several opportunities of observing the effects of accidentally touching the cornea with the cryoextractor refrigerated to about -79°C. This accident proved to be quite harmless in all cases as no lasting effect on the clarity of the cornea could be seen after the tissue...
متن کاملEffects of 5-iodo-2' -deoxyuridine and Phenylmercuric Dinaphthylmethane Disulphonate on Herpes Genitalis.
The successful treatment of thirteen cases of herpes simplex ofthe skin with 5-iodo-2'-deoxyuridine (5IDU) was reported by Hall-Smith, Corrigan, and Gilkes (1962), and a further series of 22 cases by Jackson (1963). The effects of 5IDU in 43 cases of herpetic keratitis in rabbits compared with an unspecified number of controls have been reported favourably by Kaufman, Nesburn, and Malony, (1962...
متن کاملTreatment of adenovirus infection of the eye with 5-iodo-2'-deoxyuridine. A double-blind trial.
Epidemic keratoconjunctivitis is usually caused by infection with an adenovirus, generally type 8 (Hanna, Jawetz, Mitsui, Thygeson, Kimura, and Nicholas, I957). As this is a DNA virus it might be expected to respond to treatment with 5-iodo-2'-deoxyuridine (IDU) which acts by interfering with the normal synthesis of DNA, thus preventing replication of DNA-containing viruses (Herrmann, I 96 I; S...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1963
ISSN: 0007-1161
DOI: 10.1136/bjo.47.8.449